Discussion in ' Pharmaceuticals ' started by NocturnesJan 13, Log in or Sign up. Hip Forums. Make Adderall stronger? What is a way to make the effects of Adderall stronger? Ive heard baking soda, but i figured i'd ask here first. NocturnesJan 13, Take more or do crystal Meth instead. G0dm4ch1n3Jan 21, If youre looking for a more intense amphetamine high you can try meth, or if you cant find any you could do what i used to do before i had a meth hookup, which is crush up some ritalin methylphenidate and an equal dose of adderall amphetamine salts and mix the two up.
DrugreferenceJan 22, Magical mystery tourguideJan 23, Any antacid will work. Tums or baking soda, whatever. Also try a tyrosine supplement. It helps your body make more dopamine, which adderall uses up. And as said before, methylphenidates mix well with amphetamine. Personally, I kicked my amphetamine habit. Adderall abuse drove me into a depression and it took a few months to realize it.
I'm a different person on amphetamine, and I find stimulant use inevitably makes you constantly exhausted after prolonged use. Exploring psychedelics and downers now. The only reason I think meth is worse for you is because its a street drug and therefor cut with who knows what.
The baking soda is true. However, insufflation will provide an even more intense experience.
Status Report on Role of Stimulants in Chronic Pain Management
I believe the bioavailability is higher intranasally, and obviously it hits quicker.Wookie; Yes they do use Hydroxyzine to potentiate other medications and is used for this very reason often for many different medications. It can also help with some anxiety or nervousness that Adderall can cause depending on the dose. Yo Chuck! Thanks for the response my friend. It is much appreciated. Could you give me an example of the doses that would work best together? For instance, let's say that someone had 4 30mg Adderall IR, how many 50mg Hydroxyzine would that someone take to potentiate the Adderall to plus side and not the negative?
Wookie; This is kind of tough one everyone is different because the medications work different on different people but if it's okay with your doctor start with something like twice daily on the Hydroxyzine it stays in the system longer so you don't want to increase the Adderall to fast or much but take it just as directed by your physician and make sure it is okay that you try different doses of the Hydroxyzine normally more like every 6 hours to start but see what your doctor says.
And if it's okay with the doctor you can adjust it according to how it is working.
Hope it helps you. Just remember follow the doctors orders is the most importaint to make sure the doctor is aware of what your doing or he or she may perfer a different way of doing this if nothing else give the doctor a call and get exact directions. Chuck, why would you give the ok for this? Please let us know if you did :. There is not a major or any big reaction with these 2 medications, and I also told the patient to check with a there doctor if any question about this combination but I have seen more of these prescriptions filled together than I can count.
There are much more food allergies with this combination than these 2 taken together. But thanks. Still looking for answers? Try searching for what you seek or ask your own question. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
We comply with the HONcode standard for trustworthy health information - verify here. Skip to Content. Does Hydroxyzine potentiate the effects of Adderall IR? Asked 19 Dec by Wookielove83 Updated 3 November Topics adderallattention-deficit hyperactivity disorder adhdhydroxyzine. Answer this question. Answer this question Find similar questions. Inconsistent effects of Adderrall XR? What will Help me with sleep? First time taking Adderall?
Opiate Potentiating guide (really works)
There was a problem adding your email Try again. All rights reserved. Do not copy or redistribute in any form! I've had the inattentive-type ADD symptoms as far as I can remember, and my family's problems-one being!
I've always been somewhat of an outcast with a couple friends, and a low self-esteem, but always complimented by teachers as very creative and intelligent individual. I have never been the social type because of low self-esteem, and extreme social anxiety.
The negatives that I have aforementioned have made my life, especially my childhood very depressing. I thought of committing suicide constantly, and often drew myself away from the people.
Grades suffered because I could never keep my mind on one thing, especially something I disliked, for more than 20 minutes. My sophomore year in high school my biological mother had called my school to tell them that I needed to see the counselor because extreme signs of depression were prevalent to her. I only was allowed once visit before my step mom my father had custody of me at the time had restricted the school to continue my counseling.
Finally Thanks for reading this farI was not diagnosed with ADD until I dropped out of college my freshman year, and seeked professional therapy. About a week ago, the 26th, I was prescribed 5mg pills of Adderall by my physician.
I was in for a surprise. Unknowing that Adderall is similar, and sometimes used as an alternative dance-drug, I popped my first 'hit', only the prescribed amount of 5mg, as soon as I got home. I maintained this euphoric feeling for the first two days after I started medicating, but then once again I realized "Whatever comes up must come down. The roller coaster is starting to get a little tiring, and I would like to know if there is a way I can maintain the euphoric-feeling permanently.Stimulants are a class of compounds that have a sympathomimetic or uplighting action on the central nervous system CNS.
Internal or endogenous stimulants are known as catecholamines because a portion of the molecule is catechol. The best known examples are dopamine, norepinephrine, and epinephrine. Regardless of terminology, stimulant or catecholaminergic compounds have an expanding role in pain management for a number of reasons.
They have been shown to have innate analgesic properties, in addition to potentiating opioids, enhancing some mental and physiologic functions, and treating some common comorbidities of chronic pain, including fatigue, depression, daytime sedation, obesity, and attention deficit hyperactivity disorder ADHD. Some recent basic science research will accelerate this expanded role. Recent studies provide a compelling scientific basis for the increased use of stimulant compounds in chronic pain management.
Collectively, these studies quite convincingly show that stimulants may be necessary for chronic pain control. In one study, Taylor et al found that inflamed microglia in chronic pain states do not adequately release and activate dopamine in the CNS, which is necessary for pain control.
These results have broad implications that are not restricted to the problem of pain, but are also relevant to affective disorders associated with disruption of reward circuitry. Because chronic pain causes glial activation in areas of the CNS important for mood and affect, our findings may translate to other disorders, including anxiety and depression, that demonstrate high comorbidity with chronic pain. In another study, Parent et al found low plasma norepinephrine and metanephrine concentrations in patients with chronic pain.
Other relevant research shows that descending neural pathways from the brain to the periphery generate a great deal of chronic pain. Taken together, these recent studies tell us we likely will need externally administered stimulants to substitute for lack of central cathecholaminergic activity and to make up for a peripheral, plasma catecholamine deficiency to control descending pain signals.
Given the historical effective use of stimulants in severe pain and the recent scientific evidence that catecholamine compounds are necessary for pain control, it is clear that the use of stimulants should be expanded. Physicians have been reluctant, however, to prescribe stimulants to pain patients for fear of abuse or addiction and concerns that high blood pressure and tachycardia may result.
At this time, there are no reports documenting abuse, diversion, or addiction with stimulants in patients with legitimate chronic pain. However, there are numerous reports of misuse and abuse of stimulants in patients with other conditions, especially among those being treated for ADHD. Overall, the data suggest that ADHD medication misuse and diversion are To minimize risk, certain measures are recommended. One is to use an off-label consent form when prescribing stimulants, which lays out the risks of dependence, hypertension, and tachycardia.
As when prescribing opioids, regular clinic visits and monitoring for aberrant behavior involving stimulants should be done. The risk for hypertension and tachycardia is widely overstated. Although stimulants may cause hypertension and tachycardia in patients without pain conditions, these adverse effects AEs rarely occur in chronic pain patients.
In fact, there may be a counterintuitive, physiologic effect of stimulants in chronic pain patients. Also, pain patients rarely, if ever, report euphoria with stimulants. The reason for this counterintuitive effect in chronic pain patients is somewhat unclear, but it is likely related to the oversensitization of the nervous system in chronic pain states and the deficiencies of central and peripheral catecholamines.
Practitioners obviously should monitor chronic pain patients for elevated blood pressure and pulse rates, but a reduction, not an elevation, in these physiologic measures is the usual finding in this population. Although there are obvious risks to stimulant treatment of chronic pain patients, the long positive history of their use, the absence of reported AEs and abuse in pain patients, and the need to treat certain comorbidities, make it clear that the benefits of stimulant treatment outweigh its risks.
Given the emerging and expanding use of stimulants in pain management, it is most desirable that pain practitioners have some familiarity with the history of stimulant use in pain treatment, so that all concerned parties know that this is not some new, radical development. More than a century ago, inWeber showed that catecholamines would relieve pain when he applied epinephrine adrenaline to exposed spinal cords of cats.
The cocktail consisted of morphine or diacetylmorphine heroincocaine, ethyl alcohol, and chlorpromazine for nausea. This cocktail usually was reserved for terminally ill patients with cancer or tuberculosis.
Dextroamphetamine and morphine were found to be an excellent combination for pain relief during World War II. Instead, researchers, commercial producers, and practitioners turned their attention to combining stimulants, including caffeine, into single commercial products because stimulants clearly potentiated opioids and aspirin.
The combination products of codeine with aspirin or acetaminophen and caffeine are widely known and have been highly prescribed for over 2 generations.
Although not yet widely adopted, a number of excellent studies on stimulants and opioids in combination were done between and the end of the last century.
One of the surprising and positive findings in these studies was that stimulants not only gave better pain relief, but subjects animals and humans routinely performed mentally and physically better and had less respiratory depression and sedation than with opioids alone.
InI conducted a randomized, controlled trial of dextroamphetamine with morphine in post-operative patients and clearly documented the superior pain-relieving effects of the simultaneous use of both agents.
All told, the history and research of stimulant use in chronic pain states is compelling.History and science are pretty clear: the simultaneous use of stimulants and opioids have, for over a century, been reported to be a superior combination for pain relief.Your Brain On Adderall - The Study Drug
Although these pioneering researchers lamented the non-use of this combination in their seminal study, it turns out that they may, after all, get their wish. Sophisticated pain practitioners everywhere are starting to use various combinations of stimulants and opioids to enhance their pain therapeutics. It has been long-established that amphetamines and other stimulants have an analgesic effect in their own right and significantly enhance the analgesic effects of opioids.
Herbert Snow of London in who recommended an oral mixture of morphine and cocaine for patients suffering in agony from an advanced disease. It was usually reserved for terminally ill patients with cancer or tuberculosis. Dextroamphetamine and morphine were found to be an excellent combination for pain relief during World War II.
Instead, researchers, commercial producers, and practitioners turned their attention to combining stimulants, including caffeine, into single commercial products. The combination products of codeine with aspirin or acetaminophen and caffeine are widely known and have been highly prescribed for over two generations. Although not yet widely adopted, a number of excellent studies on stimulants and opioids were done between and the end of the last century.
It is estimated that about 10 million patients in the United States now use them. The exposure of millions to opioids has given us a population of patients who now know that the opioid class of drugs is indispensable for their pain relief. Although hardly news, practitioners, patients, and families are now beginning to observe the complications of opioids including sedation, fatigue, mental dullness, constipation, falls, and hormone suppression.
Simultaneous Use of Stimulants and Opioids
Since no caring practitioner or patient who experiences pain relief with opioids is about to give them up, a stimulant added to the opioid regimen can enhance pain relief, limit opioid dosage, and prevent some opioid complications. Too often it is perceived that the endogenous endorphin-opioid receptor system is the only pain control mechanism in the central nervous system. When a chronic pain patient on opioids adds a stimulant to their regimen, they and their observing family usually note less fatigue and lethargy and accompanied by intellectual awakening and more energy.
Patients will frequently report less depression, better memory and more intense concentration ability see Table 1. Enhanced pain relief may occur with the first dosage of stimulant. Stimulants can also lower an opioid daily dosage and ease the discomfort of opioid rotation or forced withdrawal due to loss of financial support of an expensive opioid.
Stimulants generally fit a dose response curve. For safety, start with a low dosage and titrate upward over four to eight weeks until a therapeutic effect is reached. Stimulants can be given on their own fixed schedule such as two or three times a day or they can be simultaneously given with an opioid dosage.
Table 2 presents several tips on how to administer stimulants. The use of stimulants with opioids, while historic, has been a seldom-used procedure in contemporary medicine. First, what should the dosage be? Given the plethora of toxic reactions being served up by the methamphetamine-abuse epidemic, caution is advised. No one really knows what methamphetamine dosages are used by street abusers, so it is impossible to compare street dosages with low dose prescription products.
A recommended course with a selected stimulant is to start low in dosage and titrate upward over time. For example, I like to start dextroamphetamines at one of the two lowest commercial dosages, 5 or 10mg, two or three times a day.
I initially start phentermine at 30 or The second unanswered question is whether we will see long-term toxic complications of stimulants. Reports to date indicate that stimulants have negligible effects on blood pressure, heart rate, or mental abilities.Discussion in ' Opiates ' started by GdeadheadMay 23, Log in or Sign up. Hip Forums. Opiate Potentiating guide really works Discussion in ' Opiates ' started by GdeadheadMay 23, A while back I came across this guide of several methods to potentiate an opiate high.
I did not write this myself but it really does work well. I reccomend this thread be stickied What's up. Haven't shown my face in quite some time, but I haven't died or anything. Been super fucking busy with work, school, and of course, drugs. So, my opiate experience is now ridiculous. As some you may remember, I had a "opiate potentiation formula" that I thought was pretty damn good. That was when my opiate use was, TOPS, once a month. Now, I use several times a week, and only to keep my tolerance from rising and to avoid becoming physically dependant do I limit my indulgence.
And, in my opiate-induced generally junk-driven journey's, I have seriously revised my famous formula. Not more, you don't want to over power it. Tagamet HB tablets are mg each, so the recommended mg is 3 tabs.
Quinine is an ingredient in tonic water, and functions the same way as Tagamet. A large glass of straight tonic water is plenty. I prefer the "Vintage" brand. White grapefruit juice contains three ingredients that clog the CYP set. However, it doesn't clog CYP2D6 too well, which is the main one for most opes. It does strongly 'clog' CYP3A4 nicely though, and although that's almost an 'auxillary' enzyme for alot of opiates, it definitely helps out.
Again, it's cheap. An important thing to note for the grapefruit juice is the percentage of juice. This is almost a waste of your money. A very common business practice for juice companies is to create 'juice cocktails'. Look in the ingredients list, and make sure the only juice in there is white grapefruit, preferably from concentrate. Nutritionally, juices from concentrate are usually not as good. Now, some of you may be wondering WHY 'clogging' these enzymes is so beneficial.
Basically, by slowing or even completely stopping the metabolization of opiates, they last MUCH longer. Also, blood plasma levels of opiates have been shown to vastly higher when the CYP set is strongly inhibited; meaning their is a higher peak, and it lasts longer. It's a win-win situation, trust me. Benadryl diphenhydramine HCl and CPM chlorpheniramine maleate are both over-the-counter anti-histamines that increase the analgesic and euphoric properties of opiates to some extent.
They also help cut down on the ope-itch. In addition, these guys also slightly inhibit subset CYP2D6.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:. Notes: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects.
For a complete list of all side effects, click here. Bottom Line Adderall XR is a long-acting, once-daily formulation that combines four different amphetamine salts into one product and is used for the treatment of ADHD. Adderall XR is potentially addictive and can cause insomnia. Medicines that interact with Adderall XR may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Adderall XR.
An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Note that this list is not all-inclusive and includes only common medications that may interact with Adderall XR.
You should refer to the prescribing information for Adderall XR for a complete list of interactions. Adderall XR dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate [Package Insert]. Shire US Manufacturing Inc. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use AdderallXR only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Other brands: Mydayis. AdderallVyvansemethylphenidateConcertaRitalinmodafinilStratteradextroamphetamine.
Adderall XR reviews. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
We comply with the HONcode standard for trustworthy health information - verify here. Skip to Content. How it works Adderall XR is a long-acting, amphetamine-type product that consists of four different amphetamine salts dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate and amphetamine sulfate.
Experts aren't sure exactly how Adderall XR works in Attention Deficit Hyperactivity Disorder ADHD but suggest it blocks the reuptake of the neurotransmitters, dopamine, and norepinephrine, which increases their concentration in the neuronal synapse the space between two nerves. Adderall XR only needs to be given once a day.
People taking a twice-daily dosage of immediate-release Adderall immediate-release may be switched to Adderall XR at the same total daily dose taken once daily. Should be used in conjunction with other treatment options such as psychotherapy, education about the disorder, social integration advice.
Not recommended for children aged less than six years. Adderall XR is available as a generic under the name amphetamine salt combo XR. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Insomnia inability to sleepheadache, dry mouth, loss of appetite, nervousness, and nausea are the most common side effects.
May also cause heart palpitations, constipation and other GI disturbances, weight loss, changes in libido, alopecia hair losselevated blood pressure and muscle twitching, stiffness, or tightness. High potential for dependence especially when administered for long periods of time. High potential for abuse. May be sought after by drug abusers or people with addiction disorders.